Which statement about Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) is true?

• A. Asthma
• B. Eosinophilia
• C. Pulmonary infiltration
• D. All of the above

Answer: (D)

This question tests recognition of the typical features of eosinophilic granulomatosis with polyangiitis (Churg-Strauss). This disorder is a small-vessel vasculitis that classically evolves through allergic, eosinophilic, and vasculitic phases. Asthma is a prominent early feature and often precedes other manifestations. Eosinophilia—sometimes marked—in the blood and tissues is a key finding and drives many organ injuries. Pulmonary infiltrates are common, arising from eosinophilic pneumonia and inflammatory vasculitis in the lungs. Taken together, these features commonly occur in this disease, so the statement that all of the above are true best describes eosinophilic granulomatosis with polyangiitis.