Which joint is most frequently involved in osteoarthritis?

• A. Knee
• B. Wrist
• C. Ankle
• D. Hand DIP joints

Answer: (A)

Osteoarthritis tends to affect joints that bear the most weight and undergo the most use. The knee fits this pattern best because it supports the body's weight and endures a lot of mechanical stress with daily activities and varied movements. Over time, cartilage degrades, and changes in the bone beneath the cartilage (subchondral sclerosis and osteophyte formation) develop, leading to pain, stiffness, and functional limitation. Although OA can involve other joints like the hands or hips, the knee is the most commonly affected overall, which is why it’s the best answer here.