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Multiple Choice

The following diseases are secondary vasculitides, except

Distinguishing primary from secondary vasculitis helps explain why giant-cell arteritis is the exception. Secondary vasculitides arise because of an underlying condition or trigger—such as an infection (virus-associated), a drug exposure (drug-associated), or a malignancy (cancer-associated). Giant-cell arteritis, however, is a primary large-vessel vasculitis with idiopathic granulomatous inflammation of the vessels, typically in older adults, not driven by an external trigger. That makes it the exception among the listed options. The other three are classic examples of vasculitis secondary to an outside factor.

Distinguishing primary from secondary vasculitis helps explain why giant-cell arteritis is the exception. Secondary vasculitides arise because of an underlying condition or trigger—such as an infection (virus-associated), a drug exposure (drug-associated), or a malignancy (cancer-associated). Giant-cell arteritis, however, is a primary large-vessel vasculitis with idiopathic granulomatous inflammation of the vessels, typically in older adults, not driven by an external trigger. That makes it the exception among the listed options. The other three are classic examples of vasculitis secondary to an outside factor.