Anti-SSA and anti-SSB positivity is NOT typical in which disease?

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Multiple Choice

Anti-SSA and anti-SSB positivity is NOT typical in which disease?

Anti-SSA (Ro) and anti-SSB (La) antibodies are most characteristic of Sjögren's syndrome and are also commonly seen in systemic lupus erythematosus. They reflect autoimmune activity targeting exocrine glands and related tissues. ANCA-associated vasculitis, by contrast, is driven by antibodies against neutrophil cytoplasmic antigens (PR3, MPO) and presents with necrotizing vasculitis; SSA/SSB are not typical features here. So when you see anti-SSA/SSB positivity, Sjögren's syndrome is a more likely fit, and to a lesser extent SLE; their presence would not be expected in ANCA vasculitis. Note that rheumatoid arthritis can have secondary Sjögren's with SSA/SSB positivity, but that pattern remains most characteristic of Sjögren's and SLE rather than ANCA vasculitis.

Anti-SSA (Ro) and anti-SSB (La) antibodies are most characteristic of Sjögren's syndrome and are also commonly seen in systemic lupus erythematosus. They reflect autoimmune activity targeting exocrine glands and related tissues. ANCA-associated vasculitis, by contrast, is driven by antibodies against neutrophil cytoplasmic antigens (PR3, MPO) and presents with necrotizing vasculitis; SSA/SSB are not typical features here. So when you see anti-SSA/SSB positivity, Sjögren's syndrome is a more likely fit, and to a lesser extent SLE; their presence would not be expected in ANCA vasculitis. Note that rheumatoid arthritis can have secondary Sjögren's with SSA/SSB positivity, but that pattern remains most characteristic of Sjögren's and SLE rather than ANCA vasculitis.

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